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In general, GLP-1 agonists are safe and well tolerated, but there can be some side effects that are important for everyone to know
SST, SBKJ, TB, SM, JJH, BMS, JRJ, and CJ contributed to the study design
Recent work suggested that the reduction in both food intake and body weight observed in response to combined treatment with GLP-1RAs and PYY 3-36 results in synergistically-enhanced activation of discrete hypothalamic and brainstem circuits that regulate appetite, including the arcuate nucleus (ARC), the paraventricular nuclei of the hypothalamus (PVNs), the central nucleus of the amygdala (CeA), and the hindbrain (AP/NTS) 10,12,21,44
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